ABHD2: ABHD2 Protein | ABHD2 Antibody

ABHD2 Gene family

ABHD2 Protein

ABHD2 protein function

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).

ABHD2 protein expression

Tissue specificity

Present in sperm (at protein level).

ABHD2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    425.00
  • Mass (Da)
    48.00

ABHD2 Gene

ABHD2 cDNA / gene is a gene with protein product which located on 15q26.1. The ABHD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, mosquito, and frog. 215 organisms have orthologs with human gene ABHD2.