GABA-transaminase/ABAT: GABA-transaminase/ABAT Protein | GABA-transaminase/ABAT Antibody

GABA-transaminase/ABAT Protein

GABA-transaminase/ABAT protein function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

GABA-transaminase/ABAT protein expression

Tissue specificity

Liver > pancreas > brain > kidney > heart > placenta.

GABA-transaminase/ABAT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

GABA-transaminase/ABAT Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]