快速訂購

CD137L/4-1BBL/TNFSF9  抗體

All 4-1BBL  Reagents

反應性: Mouse  
應用 : FCM  
50067-R014-P-25
50067-R014-P-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
  • Slide 1
反應性: Mouse  
應用 : ELISA  
50067-RP01-400
50067-RP01-200
50067-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
    反應性: Mouse  
    應用 : FCM  
    50067-R014-C-25
    50067-R014-C-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    反應性: Mouse  
    應用 : ELISA  FCM  IF  ICC/IF  
    50067-R014-50
    50067-R014-100
    50 µg 
    100 µg 
    Add to Cart
    • Slide 1
    • Slide 1
    反應性: Mouse  
    應用 : ELISA  
    50067-RP02-50
    50067-RP02-200
    50067-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
      反應性: Mouse  
      應用 : FCM  
      50067-R014-A-25
      50067-R014-A-100
      25 Test 
      100 Tests 
      Add to Cart
      • Slide 1
      • Slide 1
      反應性: Mouse  
      應用 : FCM  
      50067-R014-F-25
      50067-R014-F-100
      25 Test 
      100 Tests 
      Add to Cart
      • Slide 1
      • Slide 1
      反應性: Rat  
      應用 : ELISA  
      80166-RP01-400
      80166-RP01-200
      80166-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
        反應性: Rat  
        應用 : ELISA  
        80166-T16-50
        80166-T16-200
        80166-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

          Browse CD137L/4-1BBL/TNFSF9 Products by

          CD137L/4-1BBL/TNFSF9 相关研究领域

          CD137L/4-1BBL/TNFSF9 相關信號通路

          CD137L/4-1BBL/TNFSF9 相關蛋白、抗體、cDNA基因、ELISA試劑盒

          CD137L/4-1BBL/TNFSF9 概述&蛋白信息

          CD137L/4-1BBL/TNFSF9 研究背景

          基因概述: The protein encoded by TNFSF9 gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by TNFSF9 gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
          General information above from NCBI
          亞單位結構: Homotrimer. {ECO:0000269|PubMed:20032458}.
          亞細胞定位: Membrane; Single-pass type II membrane protein.
          組織特異性: Expressed in brain, placenta, lung, skeletal muscle and kidney.
          相似的序列: Belongs to the tumor necrosis factor family. {ECO:0000305}.
          General information above from UniProt

          4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

          Immune Checkpoint
          Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
          Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

          Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          CD137L/4-1BBL/TNFSF9 別稱

          CD137L/4-1BBL/TNFSF9 相關文獻

        • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
        • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
        • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
        • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”