All 4-1BBL reagents are produced in house and quality controlled, including 10 4-1BBL Antibody, 31 4-1BBL Gene, 5 4-1BBL Lysate, 5 4-1BBL Protein, 1 4-1BBL qPCR. All 4-1BBL reagents are ready to use.
Recombinant 4-1BBL proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc, N-His.
4-1BBLantibodies are validated with different applications, which are ELISA, FCM, ICC/IF, IF.
4-1BBLcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each 4-1BBL of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets