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14-3-3 sigma / Stratifin / YWHAS / SFN 抗體, 兔多抗, 抗原親和純化

  • 14-3-3 sigma / Stratifin / YWHAS / SFN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
  • 14-3-3 sigma / Stratifin / YWHAS / SFN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • 14-3-3 sigma / Stratifin / YWHAS / SFN Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
產品資料評論相關產品實驗方法
小鼠 YWHAS/SFN 抗體產品資訊
免疫原:Recombinant Mouse 14-3-3 sigma / Stratifin / YWHAS / SFN protein (Catalog#50576-MNCE)
Clone ID:
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:Produced in rabbits immunized with purified, recombinant Mouse 14-3-3 sigma / Stratifin / YWHAS / SFN (rM 14-3-3 sigma / Stratifin / YWHAS / SFN; Catalog#50576-MNCE; NP_061224.2; Met 1-Ser 248). 14-3-3 sigma / Stratifin / YWHAS / SFN specific IgG was purified by Mouse 14-3-3 sigma / Stratifin / YWHAS / SFN affinity chromatography.
小鼠 YWHAS/SFN Antibody WB Application Image
小鼠 YWHAS/SFN Antibody IHC Application Image
14-3-3 sigma / Stratifin / YWHAS / SFN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse SFN in mouse skin with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
小鼠 YWHAS/SFN Antibody IP Application Image
Other YWHAS/SFN Antibody Products
14-3-3 sigma/Stratifin/YWHAS 研究背景

14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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