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人 14-3-3 sigma / Stratifin / YWHAS 蛋白 (GST 標籤)

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Human YWHAS/SFN 蛋白產品資訊
分子別稱:YWHAS
蛋白構建:A DNA sequence encoding the human SFN (NP_006133.1) (Met 1-Ser 248) was fused with the GST tag at the N-terminus.
分子種屬:Human
表達宿主:E. coli
#N/A:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human YWHAS/SFN 蛋白質控檢測
純度:> 94 % as determined by SDS-PAGE
內毒素:Please contact us for more information.
穩定性:Samples are stable for up to twelve months from date of receipt at -70℃
預測N端:Met
分子量:The recombinant human SFN/GST chimera consists of 480 amino acids and has a predicted molecular mass of 50.1 kDa. It migrates as an approxiamtely 48 kDa band in SDS-PAGE under reducing conditions.
緩衝液:Lyophilized from sterile 20mM Tris, 150mM NaCl, 10mM GSH, 25% glycerol, pH 8.0
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human YWHAS/SFN 蛋白使用指導
儲存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
#N/A:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human YWHAS/SFN Protein SDS-PAGE
Human 14-3-3 sigma / Stratifin / YWHAS Protein (GST Tag) SDS-PAGE

YWHAS/SFN 相關信號通路

Other YWHAS/SFN Recombinant Protein Products
10838-H09E
14-3-3 sigma/Stratifin/YWHAS 研究背景

14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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貨號: 10838-H09E-20
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  • Human 14-3-3 sigma / Stratifin / YWHAS Protein (GST Tag) SDS-PAGE
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”