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14-3-3 epsilon/YWHAE Antibody, Rabbit PAb, Antigen Affinity Purified

  • Human 14-3-3 epsilon/YWHAE Immunofluorescence(IF) 15721
  • Human 14-3-3 epsilon/YWHAE Immunoprecipitation(IP) 15722
  • Human 14-3-3 epsilon/YWHAE Western blot (WB) 15720
產品資料評論相關產品實驗方法
 YWHAE 抗體產品資訊
免疫原:Recombinant Human 14-3-3 epsilon/YWHAE Protein (Catalog#10842-HNCE)
Ig類型:Rabbit IgG
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:Produced in rabbits immunized with purified, recombinant Human 14-3-3 epsilon/YWHAE (rh 14-3-3 epsilon/YWHAE; Catalog#10842-HNCE; NP_006752.1; Met1-Gln255). 14-3-3 epsilon/YWHAE specific IgG was purified by Human 14-3-3 epsilon/YWHAE affinity chromatography.
Other YWHAE Antibody Products
14-3-3 epsilon/YWHAE 研究背景

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

 14-3-3 epsilon/YWHAE 參考資料
  • Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
  • Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
  • Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.
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