快速訂購

14-3-3 beta / YWHAB Antibody, Rabbit PAb, Antigen Affinity Purified

產品資料評論相關產品實驗方法
Cynomolgus YWHAB 抗體產品資訊
免疫原:Recombinant Cynomolgus 14-3-3 beta / YWHAB Protein (Catalog#90022-CNCE)
Ig類型:Rabbit IgG
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:Produced in rabbits immunized with purified, recombinant Cynomolgus 14-3-3 beta / YWHAB ( Catalog#90022-CNCE; Q4R572-2; Met2-Asn244). 14-3-3 beta / YWHAB specific IgG was purified by Cynomolgus 14-3-3 beta / YWHAB affinity chromatography.
Cynomolgus YWHAB 抗體使用指導
特異性:Cynomolgus 14-3-3 beta / YWHAB
推薦應用:IP

IP: 1-4 μL/mg of lysate

儲存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other YWHAB Antibody Products
14-3-3 beta/YWHAB 研究背景

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

Cynomolgus 14-3-3 beta/YWHAB 參考資料
  • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
  • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
  • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.
  • Product nameProduct name
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”